REGULATION OF CTNDOT CONJUGATIVE TRANSFER IS A COMPLEX AND HIGHLY COORDINATED SERIES OF EVENTS

ABSTRACT CTnDOT is a 65-kb conjugative transposon that is found in Bacteroides spp., which are one of the more abundant members within the lower human gastrointestinal tract.CTnDOT encodes resistance to the antibiotics erythromycin and tetracycline (Tc).An interesting feature of CTnDOT is that exposure to low levels of Tc induces a cascade of event

Oncogenic drivers such as KRAS extensively modulate the tumor inflammatory microenvironment (TIME) of colorectal cancer (CRC).The influence of KRAS on modulating immune cell composition remains unclear.The objective of this study was to identify signatures of infiltrative immune cells and distinctive patterns that differ between RAS wild-type (WT)